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Filtered Search Results
Medchemexpress LLC KU-57788 | 503468-95-9 | 100.0% | 413.49 | 1 ML
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KU-57788 (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. It acts as an NHEJ pathway inhibitor, and also inhibits PI3K and mTOR with IC50s of 5.0 μM and 1.7 μM, respectively.
- Highly potent and selective DNA-PK inhibitor (IC50 of 14 nM)
- NHEJ pathway inhibitor
- Inhibits PI3K (IC50 of 5.0 μM) and mTOR (IC50 of 1.7 μM)
- Inhibits the growth of liver cancer HepG2 cells dose- and time-dependently
- Reduces pDNA-PKcs (S2056) protein expression in liver cancer cells
- Affects DNA damage repair when double treated with 60Coγ IR
- Reduces the frequency of NHEJ and increases the rate of HDR following Cas9-mediated DNA cleavage
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eMolecules 486-62-4 | Medchem Express | Ononin | 10mg | 446274892 | HY-N0270 | MFCD03225479 | 430.409 | C22H22O9
Medchem Express | CH1055 (triethylamine) | 5mg | 783660610 | HY-D1464A | | 1070.290 | C60H59N7O8S2
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eMolecules 63834-59-3 | 3-(4-BROMOPHENOXY)PROPANE-1,2-DIOL | MFCD01698162 | 0.25g
AstaTech | 3-(4-BROMOPHENOXY)PROPANE-1,2-DIOL | 0.25g | 222802164 | 24246 | 95.000 | 63834-59-3 | MFCD01698162 | 247.088 | C9H11BrO3
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Medchemexpress LLC (R)-verapamil hydrochloride | 38176-02-2 | MFCD00069355 | 99.4% | C27H39ClN2O4 | 10MG
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(R)-Verapamil hydrochloride is the R-enantiomer of verapamil presented as the hydrochloride salt. It is used as a research reagent to study L-type calcium channel inhibition and modulation of drug transporters such as P-glycoprotein/MRP1. The material is supplied as a solid with high reported purity suitable for biochemical and pharmacological assays.
- High chemical purity, 99.4% by manufacturer.
- R-enantiomer for stereospecific pharmacological studies.
- Solid form suitable for long-term storage and handling.
- Suitable for studies of calcium channel activity and transporter modulation.
- Available in small lab-scale package sizes for research use.
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Medchemexpress LLC HY-116790A 10mg Medchemexpress, (+)-Penbutolol CAS:38363-41-6 Purity:>98%
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Medchemexpress, HY-116790A 10mg (+)-Penbutolol CAS:38363-41-6 (+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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![Medchemexpress LLC 3-[(2-chloro-6-fluorophenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine | 892415-28-0 | 98.9% | C16H11ClFN3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261809.png-250.jpg)
Medchemexpress LLC 3-[(2-chloro-6-fluorophenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine | 892415-28-0 | 98.9% | C16H11ClFN3S | 10MG
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EAAT2 activator 1 is a small-molecule research compound that increases protein levels of the excitatory amino acid transporter 2 (EAAT2), enhancing glutamate clearance in preclinical and in vitro studies. Supplied in solid form and as a 10 mM DMSO solution, it is intended for laboratory research use only.
- Potent activator of EAAT2, used to upregulate glutamate transporter levels.
- Available as solid and 10 mM DMSO solution formats for flexible handling.
- High purity (98.9%) suitable for biochemical and cell-based assays.
- Chemical formula C16H11ClFN3S; molecular weight 331.8 g·mol⁻¹.
- Recommended storage: powder at -20°C or 4°C; solutions at -80°C or -20°C for short term.
- For research use only; not for human or clinical use.
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Medchemexpress LLC PROTAC KRAS G12C degrader-1 | 2984236-79-3 | 99.2% | C50H54ClFN8O6 | 10MG
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PROTAC KRAS G12C degrader-1 is a cereblon-recruiting PROTAC that induces ubiquitin-proteasome degradation of KRAS G12C mutant proteins in cellular assays. It promotes CRBN-KRASG12C ternary complex formation and is used to evaluate degradation potency and downstream signaling in reporter and cancer cell lines.
- Cereblon-based recruitment mechanism for targeted degradation.
- Effective degradation of GFP-KRASG12C in reporter cells.
- High purity suitable for biochemical and cellular experiments.
- Stable as a powder under recommended cold storage conditions.
- Available in multiple small-scale quantities for research applications.
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Medchemexpress LLC Di((Z)-non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate | 1351586-50-9 | 98.0% | C41H75NO6 | 10MG
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L319 is an ionizable cationic lipidoid used to formulate synthetic liposomes and lipid nanoparticles for in vitro research. Described in patent WO-2011153493-A2 (compound 1), it is provided as a high-purity research chemical.
- Ionizable cationic lipidoid suitable for liposome and lipid nanoparticle formulation.
- High purity (98.0%) for research applications.
- Molecular weight: 678.04 g/mol; formula: C41H75NO6.
- Appearance: colorless to light yellow liquid.
- Storage stability: stable at -20°C for extended storage in pure form.
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eMolecules 2243689-80-5 | Medchem Express | DM21 | 5mg | 694125054 | HY-139441 | 1215.85 | C58H83ClN8O16S
Ambeed | (4-Aminophenyl)(morpholino)methanone | 250mg | 525000707 | A110083 | 51207-86-4 | MFCD00158788 | 206.245 | C11H14N2O2
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Medchemexpress LLC GoSlo-SR-5-69 | 1363419-31-1 | N/A | 99.3% | 470.47 g·mol-1 | C24H19N2NaO5S | 5 MG
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GoSlo-SR-5-69 is a small-molecule activator of large-conductance, calcium-activated potassium (BK) channels. It potentiates BK channel opening in electrophysiological and cellular assays (reported EC50 = 251 nM) and is used to probe BK-mediated currents and physiological responses. Supplied as a sodium sulfonate salt with high analytical purity.
- Potent BK channel activation (EC50 = 251 nM).
- High purity, tested by RP-HPLC (>99%).
- Supplied as a sodium sulfonate salt.
- Soluble in DMSO for assay preparation.
- Suitable for electrophysiology and ion-channel pharmacology studies.
- Provided in small research pack sizes for laboratory use.
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Accela Chembio Inc 2-ethoxybenzonitrile | 25g | 6609-57-0 | MFCD00001789 | 97+% | D: 1.053 | Shelf Life: 1080 Days | Regular
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2-ethoxybenzonitrile | 25g | 6609-57-0 | MFCD00001789 | 97+% | D: 1.053 | Shelf Life: 1080 Days | Regular
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Medchemexpress LLC DSM705 hydrochloride | 2989908-08-7 | MFCD34676639 | 99.6% | 440.85 g/mol | C19H20ClF3N6O | 5 MG
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DSM705 hydrochloride is a pyrrole-based dihydroorotate dehydrogenase (DHODH) inhibitor developed as an orally active antimalarial compound. It shows nanomolar potency against Plasmodium DHODHs and parasites while exhibiting no inhibition of mammalian DHODHs. The substance is supplied as a hydrochloride salt, white to off-white solid, with molecular weight 440.85 g/mol and typical purity ~99.56%.
- Potent DHODH inhibitor with nanomolar activity against Plasmodium enzymes.
- Selective for parasite DHODH over mammalian DHODHs, reducing off-target effects.
- Suitable for in vitro and in vivo antimalarial research applications.
- High purity enables reliable biochemical and cellular assays.
- Available in small research quantities for early-stage studies.
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Medchemexpress LLC 3-hydroxy agomelatine | 166526-99-4 | MFCD27996054 | 99.1% | 259.31 g/mol | C15H17NO3 | 5 MG
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3-Hydroxy agomelatine is a research-grade metabolite of agomelatine used in receptor pharmacology and metabolic studies. It acts as a 5-HT2C receptor antagonist and is supplied as an off-white to light-brown solid suitable for analytical and in vitro assays. Common applications include affinity profiling, metabolite identification, and impurity characterization.
- Acts as a 5-HT2C receptor antagonist (IC50 ≈ 3.2 μM; Ki ≈ 1.8 μM).
- Supplied as an off-white to light-brown solid for ease of handling.
- High reported purity (about 99.1%) suitable for research applications.
- Useful as a reference standard for metabolic and impurity studies.
- Available in small-mass formats and DMSO solutions for assay setup.
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Sigma Aldrich Fine Chemicals Biosciences Roflumilast >=98% (HPLC) | 162401-32-3 | MFCD00938270 | 50MG
Roflumilast >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 403.21 | 162401-32-3 | MFCD00938270 | 50MG
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Medchemexpress LLC ORIC-101 | 10 MG
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ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. It exhibits anti-cancer activity and is also a click chemistry reagent.
- Highly potent and selective glucocorticoid receptor antagonist
- EC50 of 5.6 nM
- Anti-cancer activity
- Click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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